Impacts of mesenchymal stem cells and hyaluronic acid on inflammatory indicators and antioxidant defense in experimental ankle osteoarthritis

Table 2 Effect of bone marrow mesenchymal stem cell and/ or hyaluronic acid treatments on clinical score of arthritis in osteoarthritic rats

Period croup	0 day	3rd day	%	2nd week	%	3rd week	%	4th week	%	5th week	%	6th week	%
Normal	0	0.20 ± 0.08b	-	0.20 ± 0.08b	-	0.20 ± 0.01b	-	0.10 ± 0.07c	-	0.10 ± 0.07c	-	0.10 ± 0.05c	-
Osteoarthritic control	0	3.80 ± 0.13a	1800	2.80 ± 0.20a	1300	2.60 ± 0.16a	1200	3.20 ± 0.25a	2400	2.60 ± 0.22a	2300	2.10 ± 0.21a	2000
Osteoarthritic + BMMSCs	0	3.60 ± 0.18a	-5	2.70 ± 0.21a	-4	2.40 ± 0.16a	-8	2.30 ± 0.25a	4	2.10 ± 0.23b	-13	0.70 ± 0.19b	-67
Osteoarthritic + HA	0	3.70 ± 0.15a	-3	2.80 ± 0.20a	0	2.50 ± 0.16a	-8	2.12 ± 0.13b	-16	1.70 ± 0.21b	-29	0.55 ± 0.14b	-74
Osteoarthritic + BMMSCs + HA	0	3.70 ± 0.15a	-3	2.70 ± 0.21a	-4	2.40 ± 0.16a	-8	2.50 ± 0.21a	0	2.00 ± 0.21b	-17	0.70 ± 0.19b	-67

^aP < 0.05, in the same column, values with b, c, and d are significantly different;

^bP < 0.05, in the same column, values with a, c, and d are significantly different;

^cP < 0.05, in the same column, values with a, b, and d are significantly different;

^dP < 0.05, in the same column, values with a, b, and c are significantly different.

Data are expressed as the mean ± standard of the mean (SEM) of the mean (n = 6). Percentage changes were calculated by comparing osteoarthritic control with normal and osteoarthritic-treated groups with osteoarthritic control. BMMSCs: Bone marrow mesenchymal stem cells; HA: Hyaluronic acid.