Diagnosis and treatment of chronic osteomyelitis based on nanomaterials

Figure 2 Pathophysiological mechanism of osteomyelitis. A: Leukocyte necrosis releases inflammatory mediators to destroy bone matrix and bone trabeculae, forming abscesses; B: The infected lesions spread to the adjacent bone structures through Harvard’s tube, and the intraosseous pressure is increased; C: Bone destruction and vascular obstruction resulted in different degrees of osteonecrosis and encapsulation.