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©The Author(s) 2023.
World J Orthop. Feb 18, 2023; 14(2): 55-63
Published online Feb 18, 2023. doi: 10.5312/wjo.v14.i2.55
Published online Feb 18, 2023. doi: 10.5312/wjo.v14.i2.55
Table 3 Therapeutic options for fungal arthritis
| Antifungal drugs | Indication/pathogen | Dosage |
| Fluconazole | Candidiasis | 400 mg (6 mg/kg) daily (IV/PO) |
| Histoplasmosis | ||
| Blastomycosis | ||
| Coccidioides | ||
| Cryptococcus | ||
| Voriconazole | Aspergillus | 4-6 mg/kg BD; 200 mg BD (IV/PO) |
| Candidiasis | ||
| Coccidioides | ||
| Blastomycosis | ||
| Cryptococcus | ||
| Histoplasmosis | ||
| Itraconazole | Aspergillus | 100-400 mg/d (PO) |
| Sporothrix | ||
| Candidiasis | ||
| Coccidioides | ||
| Histoplasmosis | ||
| Cryptococcus | ||
| Blastomycosis | ||
| Ketoconazole | Blastomycosis (mild to moderate cases) | 200-400 mg OD (PO) |
| Coccidioides | ||
| Cryptococcus | ||
| Histoplasmosis | ||
| Liposomal amphotericin B | Candida species (except C. lusitaniae) | 3-5 mg/kg/d (IV) |
| Cryptococcus | ||
| Aspergillus | ||
| Coccidioides | ||
| Histoplasmosis | ||
| Sporothrix | ||
| Echinocandins: Caspofungin, anidulafungin, micafungin | Candidiasis (fungicidal) | Caspofungin: 70 mg on day 1 followed by 50 mg OD (IV); anidulafungin: 200 mg on day 1 followed by 100 mg OD (IV); micafungin: 100 mg OD (IV) |
| Aspergillus (fungistatic) | ||
| 5-Flucytosine | Cryptococcus | 100 mg/kg/d divided q 6 h (PO) |
| Candida |
- Citation: Mishra A, Juneja D. Fungal arthritis: A challenging clinical entity. World J Orthop 2023; 14(2): 55-63
- URL: https://www.wjgnet.com/2218-5836/full/v14/i2/55.htm
- DOI: https://dx.doi.org/10.5312/wjo.v14.i2.55