Adjunctive platelet-rich plasma and hyaluronic acid injection after arthroscopic debridement in Kellgren-Lawrence grade 3 and 4 knee osteoarthritis

Table 3 Analysis of variance and least significance difference post hoc test for Western Ontario and McMaster Universities Osteoarthritis Index score and sub-scores

Score	Period	Arthroscopic debridement	Arthroscopic debridement + HA	Arthroscopic debridement + PRP	ANOVA P value	LSD post hoc test; P value
						I vs II	I vs III	II vs III
WOMAC score	Baseline	49.43 ± 10.33	54.43 ± 14.55	49.86 ± 7.22	0.65	0.41	0.94	0.45
	3 mo	28.57 ± 9.09	24.86 ± 12.09	19.71 ± 5.74	0.23	0.47	0.09	0.32
	5 mo	18.57 ± 7.12	14.86 ± 5.58	15.00 ± 8.45	0.56	0.34	0.36	0.97
Pain score	Baseline	12.43 ± 2.76	12.57 ± 4.50	13.14 ± 2.34	0.91	0.94	0.69	0.75
	3 mo	6.00 ± 2.65	4.43 ± 2.44	4.14 ± 1.86	0.30	0.23	0.16	0.82
	5 mo	4.14 ± 3.02	2.14 ± 0.70	1.71 ± 0.95	0.06	0.06	0.03	0.67
Stiffness score	Baseline	4.57 ± 2.15	4.57 ± 2.82	5.43 ± 3.16	0.80	1.00	0.57	0.57
	3 mo	3.00 ± 0.82	2.43 ± 1.62	1.71 ± 1.38	0.22	0.43	0.08	0.32
	5 mo	2.14 ± 2.12	0.86 ± 1.21	0.86 ± 1.07	0.22	0.14	0.14	1.00
Function score	Baseline	32.43 ± 8.89	37.29 ± 9.66	31.29 ± 6.26	0.39	0.29	0.80	0.20
	3 mo	19.57 ± 7.30	18.00 ± 8.87	13.86 ± 4.10	0.32	0.68	0.15	0.29
	5 mo	12.29 ± 3.64	11.86 ± 4.22	12.43 ± 6.80	0.98	0.83	0.96	0.84

HA: Hyaluronic acid; PRP: Platelet-rich plasma; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index. I: Arthroscopic debridement; II: Arthroscopic debridement + HA; III: Arthroscopic debridement + PRP.