Adjunctive platelet-rich plasma and hyaluronic acid injection after arthroscopic debridement in Kellgren-Lawrence grade 3 and 4 knee osteoarthritis

Table 2 Paired t-test analysis of Western Ontario and McMaster Universities Osteoarthritis Index scores and sub-scores

Treatment	Outcome	Baseline	3 mo	5 mo	Paired t-test
					Baseline vs 3 mo		Baseline vs 5 mo
					t value	P value	t value	P value
Arthroscopic debridement	WOMAC score	49.43 ± 10.33	28.57 ± 9.09	18.57 ± 7.12	5.143	0.002	8.712	0.000
	Pain score	12.43 ± 2.76	6.00 ± 2.65	4.14 ± 3.02	5.391	0.002	17.488	0.000
	Stiffness score	4.57 ± 2.15	3.00 ± 0.82	2.14 ± 2.12	2.008	0.091	2.232	0.067
	Function score	32.43 ± 8.89	19.57 ± 7.30	12.29 ± 3.64	3.658	0.011	6.134	0.001
Arthroscopic debridement + HA	WOMAC score	54.43 ± 14.55	24.86 ± 12.09	14.86 ± 5.58	4.975	0.003	7.254	0.000
	Pain score	12.57 ± 4.50	4.43 ± 2.44	2.14 ± 0.70	5.943	0.001	6.177	0.001
	Stiffness score	4.57 ± 2.82	2.43 ± 1.62	0.86 ± 1.21	1.605	0.160	2.931	0.026
	Function score	37.29 ± 9.66	18.00 ± 8.87	11.86 ± 4.22	4.559	0.004	7.0029	0.000
Arthroscopic debridement + PRP	WOMAC score	49.86 ± 7.22	19.71 ± 5.74	15.00 ± 8.45	7.827	0.000	8.105	0.000
	Pain score	13.14 ± 2.34	4.14 ± 1.86	1.71 ± 0.95	7.937	0.000	12.060	0.000
	Stiffness score	5.43 ± 3.16	1.71 ± 1.38	0.86 ± 1.07	3.176	0.019	3.600	0.011
	Function score	31.29 ± 6.26	13.86 ± 4.10	12.43 ± 6.80	6.397	0.001	5.781	0.001

HA: Hyaluronic acid; PRP: Platelet-rich plasma; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index.