Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial

doi:10.5312/wjo.v10.i9.310

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 9

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (11214)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-6) series, Tables (1-3) series.

Item

Count

PDF

755

WORD

257

HTML

6398

Figures (1-6)

420

Tables (1-3)

339

Sum=8169

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1015

Download

2030

Sum=3045

Sep 18, 2019 (publication date) through Feb 27, 2025

Times Cited of This Article

Times Cited (39)

Journal Information of This Article

Publication Name

World Journal of Orthopedics

ISSN

2218-5836

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

World J Orthop. Sep 18, 2019; 10(9): 310-326
Published online Sep 18, 2019. doi: 10.5312/wjo.v10.i9.310

Table 2 Number of patients having at least a 30% and 50% decrease in the summed score for the Western Ontario and McMaster Universities Arthritis Index and Visual Analog Scale, n (%)

	Follow-up
Variables	1^st (wk 4)	2^nd (wk 8)	3^rd (wk 12)	1^st (wk 4)	2^nd (wk 8)	3^rd (wk 12)	1^st (wk 4)	2^nd (wk 8)	3^rd (wk 12)
Variables	Group PRP-1 (Single injection; n = 28 patients)			Group PRP-2 (Double injection; n = 28 patients)			Group hyaluronic acid (n = 27 patients)
	Patients having at least a 30% decrease in the summed score for the scales
WOMAC pain score	28 (100)	27 (96.4)	24 (85.7)	28 (100)	28 (100)	28 (100)	6 (22.2)	5 (18.5)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
WOMAC stiffness score	26 (92.9)	25 (89.3)	19 (67.9)	28 (100)	28 (100)	25 (89.3)	16 (59.3)	17 (63)	5 (18.5)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
WOMAC physical function score	26 (92.9)	23 (82.1)	12 (42.9)	28 (100)	26 (92.9)	23 (82.1)	2 (7.4)	0 (0)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
Total WOMAC score	27 (96.4)	26 (92.9)	17 (60.7)	28 (100)	28 (100)	24 (85.7)	2 (7.4)	0 (0)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
	Patients having at least a 50% decrease in the summed score for the scales
WOMAC pain score	14 (50)	11 (39.3)	6 (21.4)	25 (89.3)	23 (82.1)	16 (19.3)	0 (0)	0 (0)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
WOMAC stiffness score	17 (60.7)	16 (57.1)	7 (25)	26 (92.9)	26 (92.9)	16 (57.1)	8 (29.6)	8 (29.6)	1 (3.7)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
WOMAC physical function score	5 (17.9)	5 (17.9)	1 (3.6)	17 (60.7)	11 (39.3)	5 (17.9)	0 (0)	0 (0)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
Total WOMAC score	6 (21.4)	5 (17.9)	0 (0)	19 (67.9)	17 (60.7)	7 (25)	0 (0)	0 (0)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
VAS pain score	17 (60.7)	11 (39.3)	2 (7.1)	28 (100)	25 (89.3)	17 (60.7)	3 (11.1)	2 (7.4)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-

¹In comparison with hyaluronic acid group. VAS: Visual analog scale; WOMAC: Western Ontario and McMaster Universities Arthritis Index.

Citation: Tavassoli M, Janmohammadi N, Hosseini A, Khafri S, Esmaeilnejad-Ganji SM. Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial. World J Orthop 2019; 10(9): 310-326
URL: https://www.wjgnet.com/2218-5836/full/v10/i9/310.htm
DOI: https://dx.doi.org/10.5312/wjo.v10.i9.310