Comparison of the eighth version of the American Joint Committee on Cancer manual to the seventh version for colorectal cancer: A retrospective review of our data

Table 3 American Joint Committee on Cancer 8^th edition updates for the colorectal cancer staging system

Update points	Update details	Level of evidence
Definition of distant transfer (M)	Introduction of M1c, specifically peritoneal metastasis, is an indicator of poor prognosis	I
Definition of regional lymph nodes (N)	Further introduce the definition of tumor deposit	II
Recommended additional indicators for guiding clinical practice	Lymphatic vessel infiltration: Reintroducing the meaning of L and V1 positive to correctly understand lymphatic and vascular invasion	I
Recommended additional indicators for guiding clinical practice	Microsatellite instability: Further explaining its importance as a prognostic risk and efficacy predictor	I
Recommended additional indicators for guiding clinical practice	Determine the KRAS, NRAS, and BRAF mutations as very important prognostic risk and efficacy predictors	I, II

¹L-positive infiltrates for medics and V-positive for venous infiltration.