Mismatch repair protein expression and intratumoral budding in rectal cancer are associated with an increased pathological complete response to preoperative chemoradiotherapy: A case-control study

Table 2 Analysis of 216 patients with rectal carcinoma with preoperative chemo-radiotherapy, regarding their association with presence of complete pathological response

	Univariate analysis			Multivariate analysis1
	OR	P	95%CI	OR	P	95%CI
MMR status (defective vs proficient)	2.64	0.002	1.438-4.870	2.61	0.004	1.355-5.040
Lymphovascular invasion (present vs absent)	0.7	0.094	0.066-2.860
Histologic Grade (G1-G2 vs G3)	1.24	0.442	0.709-2.203
Tumor budding [Low budding (0-4 buds) vs High budding (5 or more buds)]	2.495	0.017	1.278-4.881	2.52	0.025	1.366-4.894
Inflammatory infiltrate (present vs absent)	1.194	0.624	0.587-2.429

¹Adjusted by MMR status and high tumor budding. OR: Odds ratio; CI: Confidence interval; MMR: Mismatch repair system.