Metronomic chemotherapy for non-metastatic triple negative breast cancer: Selection is the key

Table 1 Comparing maximum tolerated dose chemotherapy vs metronomic chemotherapy

	Maximum tolerated dose chemotherapy (conventional)	Metronomic chemotherapy
Dose	High doses	Low doses or biologic optimal doses
Administration	Administered at defined intervals (3 weekly, weekly) determined by the recovery of bone marrow	Dosing frequency is continuous (weekly, every other day, daily)
Plasma concentration	Rise and fall of the plasma concentration of the drug	Sustained plasma concentration of the drug
Target	Proliferating tumor cells	Endothelial cells in the growing vasculature of the tumor
Toxicity	Acute and cumulative toxicity is a concern	Acute toxicity is rare. Cumulative toxicity is unknown, except for etoposide (related to leukemia)