Further the liquid biopsy: Gathering pieces of the puzzle of genometastasis theory

Figure 1 Circulating nucleic acids can be present in different forms. If actively released, circulating nucleic acids can be found inserted in exosomes (1) and microvesicles (2), or associated with RNA and lipoproteins forming a complex called the virosome (3). Circulating nucleic acids can be also passively released, mainly through apoptosis, in the form of oligo- or mono-nucleosome (4).