Factors influencing response to ingenol mebutate therapy for actinic keratosis of face and scalp

Table 2 Number of patients with positive scores and mean values of local skin reaction composite and single scores at each follow up visit

		Day 2	Day 3	Day 8	Day 15	Day 29	Day 57
Erythema	n (%)	130 (100)	130 (100)	129 (99.2)	128 (98.5)	107 (82.3)	49 (37.7)
	mean ± SD	1.82 ± 0.68	2.87 ± 0.58	2.38 ± 0.78	1.86 ± 0.81	1.19 ± 0.77	0.38 ± 0.50
Flaking/scaling	n (%)	4 (3.1)	12 (9.2)	55 (42.3)	112 (86.2)	45 (34.6)	0
	mean ± SD	0.05 ± 0.28	0.11 ± 0.39	0.78 ± 1.00	1.49 ± 0.87	0.43 ± 0.65	0
Crusting	n (%)	2 (1.5)	18 (13.8)	116 (89.2)	57 (43.8)	9 (6.9)	0
	mean ± SD	0.02 ± 0.12	0.17 ± 0.45	2.16 ± 0.98	0.65 ± 0.89	0.10 ± 0.39	0
Swelling	n (%)	114 (87.7)	125 (96.2)	71 (54.6)	11 (8.5)	2 (1.5)	0
	mean ± SD	1.48 ± 0.82	2.38 ± 1.08	0.85 ± 0.98	0.13 ± 0.55	0.02 ± 0.12	0
Vesiculation/pustulation	n (%)	102 (78.5)	123 (94.6)	8 (6.2)	0	0	0
	mean ± SD	1.48 ± 0.93	2.45 ± 0.86	0.06 ± 0.24	0	0	0
Ulceration	n (%)	5 (3.8)	43 (33.1)	22 (16.9)	5 (3.8)	0	0
	mean ± SD	0.04 ± 0.19	0.48 ± 0.74	0.36 ± 0.90	0.08 ± 0.45	0	0
LSR composite	mean ± SD	4.89 ± 2.14	8.43 ± 2.38	6.62 ± 2.44	4.25 ± 1.72	1.66 ± 1.28	0.35 ± 0.49

LSR: Local skin reaction.