Recurrence-free survival as a putative surrogate for overall survival in phase III trials of curative-intent treatment of colorectal liver metastases: Systematic review

Table 4 Comparison of original hazard ratio and those from linear regression formula

Studies (by author)	n total (weight %)	RFS			OS			Assumption OS HR
		HR	95%CI		HR	95%CI
Langer	107 (9)	0.78	0.46	1.31	0.77	0.42	1.4	0.87
Portier	171 (15)	0.66	0.45	0.96	0.73	0.48	1.1	0.75
Nordlinger1	342 (29)	0.78	0.61	0.99	0.87	0.66	1.14	0.87
Ychou	306 (26)	0.89	0.66	1.19	1.09	0.72	1.64	0.97
Primrose	236 (20)	1.48	1.04	2.12	1.49	0.86	2.6	1.52

¹Intention-to-treat analysis. HR: Hazard ratio; OS: Overall survival; RFS: Recurrence free survival.