Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer

doi:10.5306/wjco.v7.i5.340

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Oct 10, 2016; 7(5): 340-351
Published online Oct 10, 2016. doi: 10.5306/wjco.v7.i5.340

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Figure 2 Possible resistance pathways to epidermal growth factor receptor blockade; gain of mutations in KRAS, BRAF, and PIK3CA and upregulation of other receptor tyrosine kinases. EGFR: Epidermal growth factor receptor; mTOR: Mechanistic target of rapamycin; PI3KCA: Phosphotidylinositol-3-kinase.

Citation: Sobani ZA, Sawant A, Jafri M, Correa AK, Sahin IH. Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer. World J Clin Oncol 2016; 7(5): 340-351
URL: https://www.wjgnet.com/2218-4333/full/v7/i5/340.htm
DOI: https://dx.doi.org/10.5306/wjco.v7.i5.340