Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy

doi:10.5306/wjco.v7.i5.387

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Oct 10, 2016; 7(5): 387-394
Published online Oct 10, 2016. doi: 10.5306/wjco.v7.i5.387

Table 4 Comparison of tumor-infiltrating-lymphocyte evaluated in pre- vs post-neoadjuvant-chemotherapy samples

Population of lymphocytes	n	Pre-NAC Me ± IQR	Post-NAC Me ± IQR	P-value²	P corrected value³
Percentage
H and E whole slide	73	40 ± 15	20 ± 15	< 0.001	< 0.002¹
H and E TMA	16	30 ± 17.5	15 ± 15	0.4321
Absolute counting
CD3	22	244.5 ± 315.5	255.5 ± 267	0.8583
CD4	7	14 ± 94	32 ± 43	0.6721
CD8	21	127 ± 193.5	156 ± 90.5	0.7544
FOXP3	21	18 ± 31	12 ± 19.5	0.0917

¹P < 0.05;

²Wilcoxon signed rank test;

³Bonferroni correction. NAC: Neoadjuvant-chemotherapy; TMA: Tissue microarrays; Me ± IQR: Median ± interquartile range.

Citation: Castaneda CA, Mittendorf E, Casavilca S, Wu Y, Castillo M, Arboleda P, Nunez T, Guerra H, Barrionuevo C, Dolores-Cerna K, Belmar-Lopez C, Abugattas J, Calderon G, De La Cruz M, Cotrina M, Dunstan J, Gomez HL, Vidaurre T. Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy. World J Clin Oncol 2016; 7(5): 387-394
URL: https://www.wjgnet.com/2218-4333/full/v7/i5/387.htm
DOI: https://dx.doi.org/10.5306/wjco.v7.i5.387