Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy

doi:10.5306/wjco.v7.i5.387

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Oct 10, 2016; 7(5): 387-394
Published online Oct 10, 2016. doi: 10.5306/wjco.v7.i5.387

Table 2 Tumor infiltrating lymphocytes in pre-neoadjuvant-chemotherapy and post-neoadjuvant-chemotherapy samples (median ± interquartile range)

TIL population	(Me ± IQR)
Pre-NAC TIL
Median percentage TIL H and E full-face (n = 91)	40 ± 20
Median percentage TIL H and E TMA (n = 30)	20 ± 15
Median counting TIL CD3 (n = 28)	244.5 ± 253.8
Median counting TIL CD4 (n = 19)	48 ± 107.5
Median counting TIL CD8 (n = 28)	102 ± 98.8
Median counting TIL FOXP3 (n = 29)	22 ± 35
Post-NAC TIL
Median percentage TIL H and E (n = 80)	20 ± 15
Median percentage TIL H and E TMA (n = 58)	10 ± 5
Median counting TIL CD3 (n = 68)	156.5 ± 200.8
Median counting TIL CD4 (n = 54)	12 ± 27.5
Median counting TIL CD8 (n = 70)	75.5 ± 93.5
Median counting TIL FOXP3 (n = 70)	7.5 ± 14.5

NAC: Neoadjuvant-chemotherapy; TIL: Tumor-infiltrating-lymphocyte; TMA: Tissue microarrays; Me ± IQR: Median ± interquartile range.

Citation: Castaneda CA, Mittendorf E, Casavilca S, Wu Y, Castillo M, Arboleda P, Nunez T, Guerra H, Barrionuevo C, Dolores-Cerna K, Belmar-Lopez C, Abugattas J, Calderon G, De La Cruz M, Cotrina M, Dunstan J, Gomez HL, Vidaurre T. Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy. World J Clin Oncol 2016; 7(5): 387-394
URL: https://www.wjgnet.com/2218-4333/full/v7/i5/387.htm
DOI: https://dx.doi.org/10.5306/wjco.v7.i5.387