Copyright
©The Author(s) 2016.
World J Clin Oncol. Oct 10, 2016; 7(5): 370-379
Published online Oct 10, 2016. doi: 10.5306/wjco.v7.i5.370
Published online Oct 10, 2016. doi: 10.5306/wjco.v7.i5.370
Table 4 Phase III prospective randomized trials evaluating the equivalence or non-inferiority of accelerated partial breast irradiation with whole-breast irradiation
Trial | No. of patients | Follow-up interval (yr) | Inclusion criteria | APBI technique | 5-yr LR APBI vs WBI (%) |
TARGIT-A[45] | 3451 | 2.4 | Age ≥ 45 yr; T1, small T2, N0, N1; ductal; non-lobular and no EIC | 20 Gy in 1 fraction, IORT low energy X-rays (50 kV) | 3.3 vs 1.3 |
ELIOT[47] | 1305 | 5.8 | Age ≥ 48 yr; T ≤ 2.5 cm, N0; invasive carcinoma; quadrantectomy | 21 Gy in 1 fraction, IORT, electrons up to 9 MeV | 4.4 vs 0.4 |
RAPID (OCOG)[41] | 2135 | Pending | Age > 40 yr; T ≤ 3 cm, N0; DCIS or invasive carcinoma; negative margins | 38.5 Gy in 10 fractions (5-8 d) using 3D-CRT | Pending |
GEC-ESTRO[35] | 1184 | 5.0 | Age ≥ 40 yr; T ≤ 3 cm, pN0-Nmi; stage 0, I, II; DCIS, ductal or lobular carcinoma; margin ≥ 2 mm | 32 Gy in 8 fractions or 30.3 Gy in 7 fractions MIB HDR or 50 Gy MIB PDR (1 pulse/h, 24 h/d; 0.6-0.8 Gy/h) | 1.4 vs 0.9 |
Florence (NCT02104895)[42] | 520 | 5.0 | Age > 40 yr; T < 2.5 cm; clear margins > 5 mm | IMRT 30 Gy in 5 daily fractions | 1.5 vs 1.5 |
IMPORT-LOW | 2018 | Pending | Age ≥ 50 yr; T ≤ 3 cm, node negative; invasive adenocarcinoma; margin ≥ 2 mm | IMRT; Arm 1: 40 Gy in 15 fractions to primary tumor region + 36 Gy in 15 fractions to low-risk region (EBRT) Arm 2: 40 Gy in 15 fractions to primary tumor region (EBRT) | Pending |
IRMA (NCT01803958) | 3302 (Currently Enrolling) | Pending | Age ≥ 49 yr; T < 3 cm, N0; invasive carcinoma; margins ≥ 2 mm | 38.5 Gy in 10 fractions using 3D-CRT, BID | Pending |
SHARE (NCT01247233) | 1006 | Pending | Age ≥ 50 yr; invasive carcinoma; T ≤ 2 cm; margin≥ 2 mm; pN0 (i+/-) | 3D-CRT 40 Gy in 10 fractions, BID | Pending |
NSABP B-39/RTOG 0413 | 4300 | Pending | Age ≥ 18 yr; DCIS or invasive adenocarcinoma; stage 0, I, II (T < 3 cm); lumpectomy; margins free of tumor; ≤ 3 positive nodes | 34 Gy in 10 fractions using MIB or MammoSite®/MammoSite® ML/SAVI® or 38.5 Gy over 10 fractions using 3D-CRT | Pending |
- Citation: Tann AW, Hatch SS, Joyner MM, Wiederhold LR, Swanson TA. Accelerated partial breast irradiation: Past, present, and future. World J Clin Oncol 2016; 7(5): 370-379
- URL: https://www.wjgnet.com/2218-4333/full/v7/i5/370.htm
- DOI: https://dx.doi.org/10.5306/wjco.v7.i5.370