Accelerated partial breast irradiation: Past, present, and future

Table 1 Additional selected, non-randomized clinical experience with interstitial brachytherapy with more than 5 years follow-up

Ref.	No. of patients	Follow-up interval (yr)	Modality	Scheme	Total dose (Gy)	5-yr LR (%)	Good/excellent cosmesis
Strnad et al[57]	274	5.25	PDR/HDR	PDR = 0.6 Gy/h	PDR = 50 Gy	2.9%	90%
				HDR = 4 Gy × 8	HDR = 32 Gy
Rabinovitch et al[32,58]	98	11.3	LDR/HDR	LDR = 3.5-5 d	LDR = 45 Gy	4%	68%
				HDR = 3.4 Gy × 10	HDR = 34 Gy
Shah et al[59,60]	199	12.0	LDR/HDR	LDR 0.52 Gy/h × 96 h	LDR = 50 Gy	5% (12-yr 5%)	99%
				HDR = 4 Gy × 8	HDR = 32 Gy
				HDR = 3.4 Gy × 10	HDR = 34 Gy
King et al[27]	51	6.25	LDR/HDR	LDR = 4 d	LDR = 45 Gy	3.9%	75%
				HDR = 4 Gy × 8	HDR = 32 Gy
Ott et al[61,62]	274	5.33	PDR/HDR	PDR = 0.6 Gy/h	PDR = 49.8 Gy	2.3%	92%
				HDR = 4 Gy × 8	HDR = 32 Gy
Polgár et al[63]	45	11.1	HDR	4.33 Gy × 7	30.3 Gy	4.4% (12-yr 9.3%)	78%
				5.2 Gy × 7	36.4 Gy

HDR: High-dose rate; LDR: Low dose rate; LR: Local recurrence; PDR: Pulsed-dose rate.