Risk of second primary malignancies in a population-based study of adult patients with essential thrombocythemia

Table 3 Risk of second primary malignancies among the study population

SPM	Observed	SIR	95%CI	AER	P-value
All sites	201	1.26	1.09-1.45	37.44	0.002
Solid	162	1.15	0.98-1.35	19.43	0.074
Colorectal	12	0.66	0.34-1.15	-5.62	0.916
Lung/bronchus	31	1.31	0.89-1.86	6.67	0.133
Breast	24	1.06	0.68-1.58	1.29	0.743
Prostate	24	1.11	0.71-1.65	2.14	0.594
Kidney	10	2.40	1.15-4.42	5.27	0.014
Lymphoma	12	1.59	0.82-2.78	4.02	0.127
Leukemia	17	3.78	2.20-6.05	11.28	< 0.001
AML	10	7.74	3.71-14.24	7.86	< 0.001

AER: Absolute excess risk; SIR: Standardized incidence ratio; SPM: Second primary malignancies.