Sequential treatment in disseminated well- and intermediate-differentiated pancreatic neuroendocrine tumors: Common sense or low rationale?

Figure 1 Summary of the mode of actions of the different available alternatives for the systemic management of pancreatic neuroendocrine tumor patients. PNET: Pancreatic neuroendocrine tumor; VEGF: Vascular endothelial growth factor; PI3K: Phosphatidylinositol 3-kinase; mTOR: Mammalian target of rapamycin.