Locoregional treatment of early breast cancer with isolated tumor cells or micrometastases on sentinel lymph node biopsy

Table 6 Impact of completion axillary lymph node dissection on adjuvant therapy decision-making

Ref.	n	Variable analysed	Results						Conclusion
			Treatment arm	CT	HT	CT + HT	Any	Type
Montemurro et al[61]	566 pN0(i+)	Systemic treatments1	cALND	58	78	-	-	-	No difference
	pN1mi		ART	61	76	-	-	-
	pN1a		Absolute difference	3	2	-	-	-
Galimberti et al[23]	931 pN0(i+)	Systemic therapy	cALND	9	63	23	95	-	No difference
	pN1mi		SLNB	7	67	22	97	-
			Absolute difference	2	4	1	2	-
Aigner et al[58]	132 pN0(i+)	Administration of CT and type of CT	cALND	72.7	-	-	-	-	Relevant difference (type of CT)
	pN1mi		SLNB	77.3	-	-	-	-
	pN1a		Absolute difference	4.6	-	-	-	12.1
Pepels et al[41]	233 pN1mi	Systemic therapy	cALND	36.8	6.2	57	-	-	No difference
			SLNB	40.2	9.8	51	-	-
			Absolute difference	3.4	3.6	6	-	-
Sávolt et al[59]	474 pN0(i+)	Systemic therapy	cALND	78	87	65	-		No difference
	pN1mi		ART	69	89	58	-
	pN1a		Absolute difference	9	2	7	-
Montemurro et al[61]	321 pN0(i+)	Adjuvant chemotherapy	cALND	62	-	-	-	-	Relevant difference
	pN1mi		SLNB	52	-	-	-	-
	pN1a		Absolute difference	10	-	-	-	-

¹Proportion of patients treated with adjuvant systemic therapy, based on Adjuvant. Absolute differences in proportion of prescriptions appear in grey. cALND: Completion axillary lymph node dissection; CT: Chemotherapy; HT: Hormonal therapy; SLNB: Sentinel lymph node biopsy; ART: Axillary radiation therapy.