Locoregional treatment of early breast cancer with isolated tumor cells or micrometastases on sentinel lymph node biopsy

Table 4 Studies of prognostic factors for positive-non-sentinel lymph nodes in patients with micrometastasis or isolated tumor cells in sentinel lymph nodes

Ref.	n	Prognostic factors for positive NSLNs
		Tumor grade	Size of positive SLN	Proportion of positive SLN	Molecular subtype	Tumor size	Age	Nb of SLN examined	Presence of LVI	Histologic type	Multicentric tumor	ECE	Tumor location
Zhou et al[26]	130 (pN1mi 25%)	+	+	+	+	+	-	-	NR	NE	NE	NE	NE
Meretoja et al[16]	1000 (pN1mi 28%)	-	+	+	+	+	NR	NR	+	-	+	+	NE
Houvenaeghel et al[17]	909 (pN1mi 100%)	-	+	NR	NR	+	NR	NR	+	+	NE	NE	NE
Tvedskov et al[20]	1881 (pN1mi 100%)	-	NR	+	+	+	-	-	+	-	-	-	+

NSLN: Non-sentinel lymph node; SLN: Sentinel lymph node; LVI: Lymphovascular invasion; ECE: Evaluable capsular effraction; NR: Not reported; NE: Non evaluable.