Overview, prevention and management of chemotherapy extravasation

Table 2 Grades of Infusion site extravasation according to common terminology criteria for adverse events (V4.0, May 2009)

Adverse event	Grade
	1	2	3	4	5
Infusion site extravasation	-	Erythema with associated symptoms (e.g., edema, pain, induration, phlebitis)	Ulceration or necrosis; severe tissue damage; operative intervention indicated	Life-threatening consequences; urgent intervention indicated	Death