Therapeutic role of template-based lymphadenectomy in urothelial carcinoma of the upper urinary tract

Table 2 Reports on staging benefit of lymphadenectomy in urothelial carcinoma of the upper urinary tract

Authors	Year	Institute	Template of LND	Subject	No. of patients	Results	Staging benefits	Ref.
Roscigno	2009	Multi	Not well described	≥ pT1	1130	5 yr-CSS: pN0 77% > pNx 69% (P = 0.032) > pN+ 35% (P < 0.001)	Yes	[29]
				≥ pT2	813	5 yr-CSS: pN0 70% > pNx 58% (P = 0.017) > pN+ 33% (P < 0.001)
Abe	2010	Multi	Not well described	pT1	66	RFS: pN0 = pNx (P = 0.702)	Yes	[30]
				≥ pT2	227	RFS: pN0 > pNx (P < 0.001) = pN+ (P = 0.134)	in ≥ pT2
Burger	2011	Multi	Not well described	Organ-confined	519	CSS: pN0 = pNx = pN+	Yes	[32]
							In locally advanced disease
				Locally advanced	266	CSS: pN0 = pNx (P = 0.633) > pN+ (P < 0.001)
Lughezzani	2010	Multi	Not described	pT1, pT2	1324	CSS: T1 pN0 = pNx (P = 0.4) = pN+ (P = 0.1)	Yes	[31]
						T2 pN0 = pNx (P = 0.8) = pN+ (P = 0.1)	In ≥ pT3
				pT3, pT4	1382	CSS: T3 pN0 = pNx (P = 0.9) > pN+ (P < 0.001)
						T4 pN0 = pNx (P = 0.3) > pNx (P < 0.001)
Mason	2012	Multi	Not described	All patients	1029	OS: pN0 66.1% = pNx 66.0% (P = 0.617)	Yes	[33]
						> pN+ 22.3% (P < 0.01)
Ouzzane	2013	Multi	Not described	All patients	714	5 yr-CSS: pN0 81% = pNx 85% (P = 0.6)	Yes	[34]
						> pN+ 47% (P < 0.001)	but in T1
				≥ pT2	337	CSS: pN0 = pNx (P = 0.44) = pN+ (P < 0.15)
TWMU	2015	Single	Well described	All patients	314	5 yr-CSS: pN0 84% > pNx 70% (P = 0.02)	Yes	-
						> pN+ 31% (P < 0.001)
				≥ pT2	212	5 yr-CSS: pN0 79% > pNx 59% (P < 0.007)
						> pN+ 31% (P < 0.004)

LND: Lymphadenectomy; CSS: Cancer-specific survival; RFS: Recurrence-free survival; LNs: Lymph nodes; CompLND: Complete lymphadenectomy; DFS: Disease free survival; OS: Overall survival.