Copyright
©The Author(s) 2015.
World J Clin Oncol. Oct 10, 2015; 6(5): 111-132
Published online Oct 10, 2015. doi: 10.5306/wjco.v6.i5.111
Published online Oct 10, 2015. doi: 10.5306/wjco.v6.i5.111
Table 3 Potential tumor suppressor microRNAs
MicroRNA | H. pylori | GC | Targets | Consequences/associations |
miR-185 | ↓ | DNMT1 and EZH2 | DNA methylation; proliferation; EMT; LNM; poor prognosis | |
miR-204 | ↓ | SIRT1 | EMT; invasion | |
miR-106b | ↓ | Proliferation (TGF-Β induced cell cycle arrest suppression) | ||
miR-320 | ↓ | ↓ | Mcl-1 | Apoptosis inhibition; progression of prenoplastic conditions |
Relapse of tumors; chemoterapeutic resistance | ||||
miR-101, | ↓ | ↓ | Mcl-1 | Apoptosis inhibition |
miR-515-5p | SOC2; DNMT1 | Let-7 attenuation | ||
miR-490-3p | ↓ | ↓ | Cyclin B1 | EMT; proliferation; colony formation; migration; invasion |
SMARCD1 | Metastasis and poorer survival | |||
Decreased through the spectrum of gastric carcinogenesis | ||||
miR-370 | ↓ | ↓ | FoxM1 | ↓p27 expression; cell cycle progression and proliferation |
Decreased through the spectrum of gastric carcinogenesis | ||||
miR-328 | ↓ | CD44v9 | Survival and proliferation of metaplastic cells | |
Let-7 | ↓ | ↓ | Ras | Cell proliferation and colony formation |
c-myc | ||||
HMGA2 | Migration and invasion | |||
Cthrc1 | ||||
miR-200, | ↓ | ↓ | ZEB1/2 | Epithelial differentiation; EMT suppression |
miR-141, | Decreased E-cadherin, inhibition of migration and invasion | |||
miR-429 | Cyclin D1 | Proliferation | ||
Bcl-2|XIAP | Apoptosis inhibition | |||
Tumor size, lymphatic invasion and LNM | ||||
miR-141 | ↓ | FGFR2 | Proliferation | |
miR-375 | ↓ | ↓ | MDM2 | p53 inactivation |
JAK2/STAT3 | Neoplastic transformation; proliferation and migration | |||
3/3/2014 | Inhibition of apoptosis | |||
PDK1 | PI3K/Akt signaling pathway activation | |||
miR-524-5p | ↓ | Jagged-1; Hes-1 | Cell proliferation and invasion | |
miR-449 | ↓ | ↓ | Cyclin E2|Met | Proliferation, angiogenesis, invasion and metastasis |
Gemini|SIRT1 | ||||
miR-203 | ↓ | ↓ | CASK | Cell growth, colony formation and cell invasion |
miR-29a | ↓ | p42.3; Mcl-1 | Cell cycle progression and proliferation | |
miR-29c | ||||
miR-15b, 16, 34, 181b, 497 | ↓ | Bcl-2 | Apoptosis inhibition | |
miR-218 | ↓ | ↓ | ECOP | Activation of NF-κB and increased COX-2; apoptosis inhibition |
SLIT/ROBO1 | Invasion and metastasis |
-
Citation: Libânio D, Dinis-Ribeiro M, Pimentel-Nunes P.
Helicobacter pylori and microRNAs: Relation with innate immunity and progression of preneoplastic conditions. World J Clin Oncol 2015; 6(5): 111-132 - URL: https://www.wjgnet.com/2218-4333/full/v6/i5/111.htm
- DOI: https://dx.doi.org/10.5306/wjco.v6.i5.111