Helicobacter pylori and microRNAs: Relation with innate immunity and progression of preneoplastic conditions

doi:10.5306/wjco.v6.i5.111

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World Journal of Clinical Oncology

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World J Clin Oncol. Oct 10, 2015; 6(5): 111-132
Published online Oct 10, 2015. doi: 10.5306/wjco.v6.i5.111

Table 1 MicroRNAs reduced by DNA methylation in Helicobacter pylori infection

MicroRNA	Targets	Consequences/associations
miR-210	STMN1	Aberrant proliferation
miR-210	DIMT1	Increased H. pylori content, atrophy and neutrophil and mononuclear infiltration
miR-375	MDM2	p53 inhibition
	JAK1/STAT3	JAK1/STAT3 activation and neoplastic transformation
	14-3-3	Bcl binding and cell survival
	PDK1	PI3K/Akt pathway
miR-124	CDK6	Cell cycle progression
Let-7a	c-myc and DNMT3B	Ras pathway activation
miR-34	Bcl-2	Apoptosis inhibition
miR-10b	MAPs	Microtubule-associated protein oncogene
miR-185	DNMT1 and EZH2	Proliferation and EMT
miR-185	DNMT1 and EZH2	LNM and poorer prognosis
miR-490-3p	Cyclin B1	EMT; proliferation; colony formation; migration; invasion
	SMARCD1	Metastasis and poorer survival
		Decreased through the spectrum of gastric carcinogenesis

STMN1: Stathmin/oncoprotein 18; DIMT1: DIM1 dimethyladenosine transferase 1 homolog (S. cerevesiae); MDM2: Mouse double minute 2 homolog/E3 ubiquitin-protein ligase Mdm2; JAK1: Janus kinase 1; STAT3: Signal transducer and activator of transcription 3; PDK1: Phosphoinositide-dependent kinase-1; CDK6: Cyclin-dependent kinase 6; DNMT3B: DNA (cytosine-5-)-methyltransferase 3 beta; Bcl-2: B-cell lymphoma 2; MAPs: Microtubule-associated proteins; DNMT1: DNA (cytosine-5)-methyltransferase 1; EZH2: Enhancer of zeste homolog 2; EMT: Epithelial-mesenchymal transition; LNM: Lymph node metastasis; SMARCD1: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1.

Citation: Libânio D, Dinis-Ribeiro M, Pimentel-Nunes P. Helicobacter pylori and microRNAs: Relation with innate immunity and progression of preneoplastic conditions. World J Clin Oncol 2015; 6(5): 111-132
URL: https://www.wjgnet.com/2218-4333/full/v6/i5/111.htm
DOI: https://dx.doi.org/10.5306/wjco.v6.i5.111