Helicobacter pylori and microRNAs: Relation with innate immunity and progression of preneoplastic conditions

doi:10.5306/wjco.v6.i5.111

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 6, Issue 5

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7725)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Tables (1-3) series.

Item

Count

PDF

545

WORD

372

HTML

3491

Tables (1-3)

177

Sum=4585

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1325

Download

1815

Sum=3140

Oct 10, 2015 (publication date) through Jul 23, 2024

Times Cited of This Article

Times Cited (28)

Journal Information of This Article

Publication Name

World Journal of Clinical Oncology

ISSN

2218-4333

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Clin Oncol. Oct 10, 2015; 6(5): 111-132
Published online Oct 10, 2015. doi: 10.5306/wjco.v6.i5.111

Table 1 MicroRNAs reduced by DNA methylation in Helicobacter pylori infection

MicroRNA	Targets	Consequences/associations
miR-210	STMN1	Aberrant proliferation
miR-210	DIMT1	Increased H. pylori content, atrophy and neutrophil and mononuclear infiltration
miR-375	MDM2	p53 inhibition
	JAK1/STAT3	JAK1/STAT3 activation and neoplastic transformation
	14-3-3	Bcl binding and cell survival
	PDK1	PI3K/Akt pathway
miR-124	CDK6	Cell cycle progression
Let-7a	c-myc and DNMT3B	Ras pathway activation
miR-34	Bcl-2	Apoptosis inhibition
miR-10b	MAPs	Microtubule-associated protein oncogene
miR-185	DNMT1 and EZH2	Proliferation and EMT
miR-185	DNMT1 and EZH2	LNM and poorer prognosis
miR-490-3p	Cyclin B1	EMT; proliferation; colony formation; migration; invasion
	SMARCD1	Metastasis and poorer survival
		Decreased through the spectrum of gastric carcinogenesis

STMN1: Stathmin/oncoprotein 18; DIMT1: DIM1 dimethyladenosine transferase 1 homolog (S. cerevesiae); MDM2: Mouse double minute 2 homolog/E3 ubiquitin-protein ligase Mdm2; JAK1: Janus kinase 1; STAT3: Signal transducer and activator of transcription 3; PDK1: Phosphoinositide-dependent kinase-1; CDK6: Cyclin-dependent kinase 6; DNMT3B: DNA (cytosine-5-)-methyltransferase 3 beta; Bcl-2: B-cell lymphoma 2; MAPs: Microtubule-associated proteins; DNMT1: DNA (cytosine-5)-methyltransferase 1; EZH2: Enhancer of zeste homolog 2; EMT: Epithelial-mesenchymal transition; LNM: Lymph node metastasis; SMARCD1: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1.

Citation: Libânio D, Dinis-Ribeiro M, Pimentel-Nunes P. Helicobacter pylori and microRNAs: Relation with innate immunity and progression of preneoplastic conditions. World J Clin Oncol 2015; 6(5): 111-132
URL: https://www.wjgnet.com/2218-4333/full/v6/i5/111.htm
DOI: https://dx.doi.org/10.5306/wjco.v6.i5.111