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©The Author(s) 2015.
World J Clin Oncol. Aug 10, 2015; 6(4): 45-56
Published online Aug 10, 2015. doi: 10.5306/wjco.v6.i4.45
Published online Aug 10, 2015. doi: 10.5306/wjco.v6.i4.45
Table 2 Relevant second- and third-line phase III trials
Trial | Comparison | Populationcharacteristics | Efficacy in allpatients | Efficacy insubgroupenriched for EGFR wt | Mutationalanalysis | Efficacy bymutationalstatus |
BR.21[1,21] | E (n = 488) vs P (n = 243) | Second line (51%) or third line (49%); nonADC, 50%; non-Asian, 87% | OS for E, 6.7 mo; OS for P, 4.7 mo; HR 0.70; P < 0.001 | NonADC HR, 0.8; non-Asian HR, 0.8 | n = 204 (27.9%); EGFR activating mutation, 34 | EGFR mutated: OS HR, 0.55; EGFR wt OS HR, 0.74; interaction P = 0.47 |
ISEL[20,23] | G (n = 959) vs P (n = 480) | Second line (49%) or third line (51%); nonADC 52%; non-Asian, 90% | OS for G, 5.6 mo; OS for P, 5.1 mo; HR, 0.89; P = 0.089 | NonADC HR < 1.01; non-Asian HR = 0.92 | n = 215 (14.9%); activating EGFR mutation, 26 | NR |
INTEREST[24,25] | G (n = 723) vs D (n = 710) | Second line (84%) or third line (16%); nonADC, 44%; non-Asian, 78% | OS for G, 7.6 mo; OS for D, 8 mo; HR, 1.02 (met non inferiority criteria) | NonADC HR < 11; non-Asian HR = 11 | n = 297 (20.7%); activating EGFR mutation, 44 | EGFR mutated: OS HR, 0.83; EGFR wt: OS HR, 1.02; interaction P = 0.59 |
TITAN[26] | E (n = 203) vs D/Pem (n = 221) | Second line; non-Asian, 86%; nonADC, 55% | OS for E, 5.3 mo; OS for D/Pem, 5.5 mo; HR = 0.96; P = 0.73 | Squamous OS HR = 0.86; non-Asian OS HR = 0.94 | n = 167 (39.3%); activating EGFR mutation, 18 | EGFR mutated: OS HR = 1.19; EGFR wt: OS HR = 0.85 |
HORG[27] | E (n = 166) vs Pem (n = 166) | Second line (57%) or third line (43%); nonADC, 77.5%; non-Asian, 100% | PFS for E, 3.6 mo; PFS for Pem 2.9 mo; P = 0.136; OS for E, 8.2 mo; OS for Pem, 10.1 mo; P = 0.986 | Squamous OS HR = 1.97 | n = 123 (37%); activating EGFR mutations, 11 | NR |
- Citation: Arriola E, Taus &, Casadevall D. Is there a role for epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor wild-type non-small cell lung cancer? World J Clin Oncol 2015; 6(4): 45-56
- URL: https://www.wjgnet.com/2218-4333/full/v6/i4/45.htm
- DOI: https://dx.doi.org/10.5306/wjco.v6.i4.45