Breast cancer phenotypes regulated by tissue factor-factor VII pathway: Possible therapeutic targets

Figure 3 Possible mechanisms of expression and functional regulation of tissue factor and coagulation factor VII in breast cancer cells. Schematic overview summarizing the multiple mechanisms of gene expression, functional tuning, and intracellular signaling in breast cancer cells, as described in this review. It has been suggested that breast cancer cell phenotypes associated with the TF-fVII pathway may be specifically controlled via multiple autocrine and/or paracrine mechanisms, depending on tumor microenvironmental conditions. EGFR: Epidermal growth factor receptor; EPCR: Endothelial protein C receptor; FVII: Coagulation factor VII; TF: Tissue factor.