Association of survivin splice variants with prognosis and treatment of breast cancer

Figure 1 Survivin functions that contribute to tumor development and metastasis; chromosomal passenger complex, inner centromere protein, hepatitis B X-linked interacting protein and X-linked inhibitor of apoptosis protein, angiopoietin-1, vascular endothelial growth factor receptor, receptor tyrosine kinase 2 (modified from ref. [59]). CPC: Chromosomal passenger complex; INCEP: Inner centromere protein; HBXIP: Hepatitis B X-linked interacting protein; XIAP: X-linked inhibitor of apoptosis protein; Ang1: Angiopoietin-1; VEGFR: Vascular endothelial growth factor receptor; Tie2: Tyrosine kinase 2.