Chemotherapy advances in locally advanced head and neck cancer

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Dec 10, 2014 (publication date) through Nov 26, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Dec 10, 2014; 5(5): 966-972
Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.966

Table 5 Concurrent regimens after induction

Study	Concurrent chemotherapy	Radiation	Notes
Tax 323	None	Conventional (66 to 70 Gy), accelerated (70 Gy) or hyperfractionated (74 Gy)	Only study not to use concurrent chemotherapy
Tax 324	Carboplatin AUC 1.5, weekly	Radiation 2 Gy per day, 5 d a week for a total of 70-74 Gy
PARADIGM: responders	Carboplatin AUC 1.5, weekly	70 Gy over 7 wk	Regimen varied by response to induction
PARADIGM: non-responders	Docetaxel 20 mg/m² weekly	Accelerated concomitant boost over 6 wk (72 Gy)	Regimen varied by response to induction
DeCIDE	CRT: five 14 d cycles of docetaxel (day 1), fluorouracil (day 0-4) and hydroxyurea (day 0-4)	Twice daily radiation (day 1-5)	Split course radiation

Citation: Georges P, Rajagopalan K, Leon C, Singh P, Ahmad N, Nader K, Kubicek GJ. Chemotherapy advances in locally advanced head and neck cancer. World J Clin Oncol 2014; 5(5): 966-972
URL: https://www.wjgnet.com/2218-4333/full/v5/i5/966.htm
DOI: https://dx.doi.org/10.5306/wjco.v5.i5.966