Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity

Table 1 Receptor-targeted photodynamic therapy on breast cancer cells

Targeted receptor	Photosensitizer	Result	Ref.
Estradiol receptor	Tetraphenylporphyrin	High-affinity conjugate protein binding	James et al[19]
Estradiol receptor	Tetraphenylporphyrin	High-affinity conjugate cell binding	Swamy et al[20]
Estradiol receptor	Pyropheophorbide a	Conjugate-selective cell death	Fernandez Gacio et al[21]
Estradiol receptor	Pyropheophorbide a	Conjugate-selective cell death	El-Akra et al[22]
Estradiol receptor	Pyropheophorbide a	High conjugate internalization	Sadler et al[23]
Estradiol receptor	Chlorin e6-dimethyl ester	Conjugate-selective cell death	Swamy et al[24]
Human epidermal growth factor receptor	Verteporfin and pyropheophorbide a	Conjugate-selective but less phototoxic	Savellano et al[25]
Human epidermal growth factor receptor	Verteporfin and pyropheophorbide a	Conjugate-selective cell death	Bhatti et al[26]
Human epidermal growth factor receptor	Zinc phthalocyanine (plus nanoparticules)	Conjugate-selective cell death	Stuchinskaya et al[27]
Human epidermal growth factor receptor	Sn-(IV) chlorin e6 monoethylenediamine	Conjugate-selective cell death	Gijsens et al[32]
Tisular factor (factor VII receptor)	Verteporfin	Conjugate-selective cell death	Hu et al[28]
Tisular factor (factor VII receptor)	Chlorin e6	Conjugate-selective cell death	Duanmu et al[29]
Gonadotropin-releasing hormone receptor	Zinc phthalocyanine	Conjugate-selective cell death	Xu et al[30]
Gonadotropin-releasing hormone receptor	Protoporphyrin IX	Conjugate-selective cell death	Rahimipour et al[31]