Association of survivin splice variants with prognosis and treatment of breast cancer

doi:10.5306/wjco.v5.i5.883

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Dec 10, 2014; 5(5): 883-894
Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.883

Table 2 Panel of 21 genes used in oncotype DX breast cancer assay

Proliferation group	Invasion group	Estrogen group	HER2 group		Reference genes
Ki-67¹	ST3	ER	GRB7 (growth factor receptor-bound protein 7)	GSTM1¹	ACTB¹
STK15¹	CTSL2	PR¹	HER2 [human EGF (epidermal growth factor) receptor 2]	CD68	GAPDH¹
BIRC5 (Survivin)¹		Bcl2			RPLPO¹
CCNB1¹		SCUBE2 [Signal peptide CUB (complement proteins C1r/C1s, Uegf, and Bmp 1)-EGF domain-containing protein 2]		BAG1	GUS¹
MYBL2¹					TFRC¹

¹Genes used in 12-gene oncotype DX for ductal carcinoma in situ. ER: Estrogen receptor; PR: Progesterone receptor; Bcl2: B-cell CLL/lymphoma 2; ST3: Stromelysin 3; CTSL2: Cathepsin L2; Ki-67: Kinase inhibitor; STK15: Serine/threonine kinase 15; CCNB1: Cyclin B1; MYBL2: Myeloblastosis family transcription factor-like 2; ACTB: Beta-actin; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; RPLPO: Ribosomal phosphoprotein; GUS: β-glucuronidase; TFRC: Transferrin receptor; GSTM1: Glutathione S-transferase M1 gene; CD68: CD68 molecule; BAG1: Bcl2–associated athanogene 1.

Citation: Pavlidou A, Kroupis C, Dimas K. Association of survivin splice variants with prognosis and treatment of breast cancer. World J Clin Oncol 2014; 5(5): 883-894
URL: https://www.wjgnet.com/2218-4333/full/v5/i5/883.htm
DOI: https://dx.doi.org/10.5306/wjco.v5.i5.883