Association of survivin splice variants with prognosis and treatment of breast cancer

Table 1 Summarized data from research articles that examined the expression of survivin transcript variants (used method is provided) accordingly to clinicopathological characteristics of patients and their survival

Ref.	Examined variants	Methods	Association with patient characteristics	Conclusion
Végran et al[22]	wt, sur2b, surΔΕx3, sur3b, sur2a	Real time qPCR	Tumor grade, estrogen receptors, lymph nodes	High expression sur3b tumors had shorter OS and DFS
Span et al[23]	wt, sur2b, surΔΕx3, sur3b, sur2a	Reverse transcription qPCR	Age, tumor grade, lymph nodes, steroid hormone receptors	High expression of sur2a, sur3b and wt indicate poorer prognosis
Ryan et al[10]	wt, sur2b, surΔΕx3	Reverse transcription qPCR, Western blotting	Tumor size, nodal metastases, breast cancer type	Wt and surΔΕx3 were correlated posively with apoptosis
Pavlidou et al[4]	wt, sur2b, surΔΕx3	Real time qPCR	Tumor grade, estrogen receptors	Sur2b/wt had significant association with estrogen receptors
Athanassiadou et al[24]	wt	Immunocytochemistry, immunohistochemistry	Grade, lymph nodes, tumor size	increased wt may indicate a worse prognosis

wt: Wild-type surviving; sur2b: Survivin-2b; surΔΕx3: Survivin-ΔΕx3; sur3b: Survivin-3b; sur2a: Survivin-2a; qPCR: Quantitative polymerase chain reaction; OS: Overall survival; DFS: Disease free survival.