Palliative radiotherapy for bone metastases from lung cancer: Evidence-based medicine?

Table 4 Grey shading indicates dose-fractionation schedules which would be supported by current evidence

Case	N treating with EBRT	8Gy/1	20Gy/5	30Gy/10	Other	Median (Range)
Uncomplicated-non-spine
Nakamura case 1 (Japan, 2012)	51	13.70%	9.80%	66.70%	9.80%	NR (NR)
Uncomplicated-spine
Hartsell case 2 (United States, 1998)	229	4% recommended < 30Gy		76% recommended 30-35Gy 20% recommended > 35Gy		NR (15Gy/5 – 47.5Gy/25)
Nakamura case 2 (Japan 2012)	51	5.90%	3.90%	78.40%	11.80%	NR (NR)
Chow case 3 (Canada, 2000)	171	15.80%	66.10%	8.80%	9.4%3	NR (8Gy/1 – 30Gy/10)
Chow case 2 (Canada, 2000)	170	15.90%	64.70%	8.20%	11.2%3	NR (8Gy/1 – 30Gy/10)
Fairchild case 3 (Intl, 2009)	867	18.3%2	19.8%2	41.9%2	20.00%	30Gy/10 (3Gy/1 - 55Gy/22)
De Bari case 2 (Italy, 2011)	107€	22.20%	50.10%	26.80%	0.90%	NR (NR)
Roos case 3 (Aust/NZ, 2000)	531€	39.6%€	35.8%€	15.1%€	9.4%€	NR (8Gy/1 - 40Gy/18)
Complicated-neuropathic pain
Nakamura case 3 (Japan, 2012)	52	0%	5.80%	78.80%	15.40%	NR (NR)
Fairchild case 4 (Intl, 2009)	844	6.6%2	29.0%2	42.8%2	21.60%	30Gy/10 (3Gy/1 – 45Gy/18)
Roos case 4 (Aust/NZ, 2000)	531€	13.2%€	52.8%€	24.5%€	9.4%€	NR (8Gy/1 - 40Gy/20)
Complicated-impending spinal cord compression and impending pathologic fracture
De Bari case 4 (Italy, 2011)	113€	30.60%	25.80%	28.20%	15.4%3	NR (NR)

¹41 specialists/12 trainees;

²Takes into account multiple dose fractionation schemes listed per respondent;

³Includes unknown/missing responses; €: Extrapolated from data reported or from figure. EBRT: External beam radiotherapy; Intl: International; NR: Not reported.