Epidermal growth factor receptor tyrosine kinase inhibitors for non-small cell lung cancer

Figure 3 First- and second-line treatment strategies for activating epidermal growth factor receptor-mutated advanced non-small cell lung cancer. First- or second-generation EGFR-tyrosine kinase inhibitors (TKIs), including gefitinib, erlotinib and afatinib, are recommended as initial EGFR-TKI therapy (A and B). First-line gefitinib is recommended in patients with poorer performance status who cannot be treated with systemic chemotherapy. First- (C) or second-line (A and B) cytotoxic chemotherapy is recommended in chemotherapy naïve patients. Subsequent erlotinib may be useful in specific patients who failed gefitinib (A).