C4.4A as a biomarker in pulmonary adenocarcinoma and squamous cell carcinoma

Figure 2 C4. 4A in pulmonary squamous cell carcinoma. Panels A-E: C4.4A expression as detected by immunohistochemistry with a polyclonal antibody in normal bronchial epithelium (A), hyperplasia (B), metaplasia (C), dysplasia (D) and invasive squamous cell carcinoma (SCC) (E). A, B, D and C, E are reproduced with permission from Jacobsen et al^[34], 2012 and BestPractice Onkologi, Denmark^[89], respectively. Panel F: Kaplan-Meier curves for the survival of SCC patients, which is independent of C4.4A scores, here stratified by tertiles (red: Lowest level of C4.4A; blue: Intermediate level of C4.4A; green: Highest level of C4.4A). Modified from Jacobsen et al^[33], 2013.