Epidermal growth factor receptor tyrosine kinase inhibitors for non-small cell lung cancer

doi:10.5306/wjco.v5.i4.646

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Oct 10, 2014 (publication date) through Jul 24, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Oct 10, 2014; 5(4): 646-659
Published online Oct 10, 2014. doi: 10.5306/wjco.v5.i4.646

Table 7 Ongoing trials for advanced activating epidermal growth factor receptor -mutated non-small cell lung cancer

Line	Trial	Phase	Treatment	Primary endpoint
First	LUX-Lung 7 (NCT01466660)	IIb	Afatinib vs Gefitinib	PFS/OS
	ARCHER-1050 (NCT01774721)	III	Dacomitinib vs Gefitinib	PFS
	Tamiya et al[65] (UMIN000005503)	II	CBDCA + TS-1 + gefitinib	PFS
	NEJ 009 (UMIN000006340)	III	CBDCA + PEM + gefitinib vs Gefitinib	OS
Second/third	WJOG (UMIN000002014)	III	Gefitinib vs Erlotinib	PFS
	IMPRESS (NCT01544179)	III	Continuation of gefitinib + CDDP + PEM vs CDDP+PEM	PFS
	JMTO12-01 (UMIN000007765)	II	Continuation of gefitinib + DOC/PEM vs DOC/PEM	PFS

EGFR: Epidermal growth factor receptor; NSCLC: Non-small cell lung cancer; PFS: Progression-free survival; OS: Overall survival; CBDCA: Carboplatin; PEM: Pemetrexed; CDDP: Cisplatin; DOC: Docetaxel.

Citation: Asami K, Atagi S. Epidermal growth factor receptor tyrosine kinase inhibitors for non-small cell lung cancer. World J Clin Oncol 2014; 5(4): 646-659
URL: https://www.wjgnet.com/2218-4333/full/v5/i4/646.htm
DOI: https://dx.doi.org/10.5306/wjco.v5.i4.646