MicroRNAs as lung cancer biomarkers

Table 2 MiRNAs as biomarkers for the prognosis and to predict response to therapy

miRNA	Experiment	Scope	Sample	Ref.
let-7a family (DOWN)	lung cancer tissue vs normal	NSCLC poor postoperative survival	Solid, (not specified)	[26]
mir-155, mir-17-3p, mir-106a, mir-93, mir-21 (UP) let-7a-2, let-7b (DOWN)	AD vs SCC	AD poor survival	Solid, (not specified)	[28]
miR-221, let-7a (DOWN) miR-137, miR-182-3p, miR-372 (UP)	NSCLC vs normal	NSCLC poor survival	Solid, snap frozen	[83]
miR-146b, miR-191, miR-155, miR-15a, miR-511, miR-100, miR-10a, miR-21, miR-126 (UP) miR-206, miR-299-3p, miR-122a, miR-513, miR-184, miR-453, miR-379, miR-202, miR-494, miR-432, miR-370 (DOWN)	SCC vs normal	SCC Overall Survival	Solid, snap frozen	[72]
miR-34a (DOWN)	NSCLC vs normal	NSCLC Probability of relapse	Solid, (not specified)	[84]
mir-124-5p, mir-146b-3p, mir-200b-5p, mir-30c-1-3p, mir-510, mir-585, mir-630, mir-657, mir-708 (relative expression)	stage I NSCLC vs normal	Stage I NSCLC recurrence	Solid, formalin-fixed, paraffin-embedded (FFPE)	[64]
miR-16 (UP)	NSCLC vs normal	NSCLC poor survival	Solid, (not specified)	[86]
miR-143 (DOWN)	Lung cancer tissue vs normal	smoking status	Solid, snap frozen	[88]
miR-21 (UP) miR-181a (DOWN)	Lung cancer tissue vs normal	NSCLC poor survival	Solid, snap frozen	[88]
miR-25, miR-34c-5p, miR-191, let-7e, miR-34a (DOWN)	AD vs SCC	SCC survival	Solid, formalin-fixed, paraffin-embedded (FFPE)	[71]
miR-31 (UP)	SCC vs normal	SCC poor survival	Solid, snap frozen	[73]
miR-325, miR-326, miR-328, miR-329-2-pre, miR-330-3p, miR-500a-3p, miR-370, miR-650-pre (UP)	BM − NSCLC vs BM + NSCLC	NSCLC, risk for brain metastasis	Solid, formalin-fixed, paraffin-embedded (FFPE)	[89]
miR-21 (UP)		Platinum-based chemotherapy-resistant NSCLC patients	Solid, snap frozen	[90]
miR-196a-2 SNP	Treatment vs genotype	Severe toxicity after platinum-based chemotherapy of advanced NSCLC patients	Genomic DNA from peripheral leukocytes	[91]
miR-128b (UP)		NSCLC samples correlated with clinical response and survival following gefitinib treatment	Microdissected primary surgically resected NSCLC tumors	[92]
miR-30b, miR-30c		Regulated by EGFR and hepatocyte growth factor (MET) receptor tyrosine kinase	Solid, Lung tumor tissue samples	[93]
miR-30b, miR-30c		Prognostic predictors in NSCLC patients who underwent first line treatment with TKIs	Solid, formalin-fixed, paraffin-embedded (FFPE)	[94]

NSCLC: Non-small cell lung cancer; AD: Adenocarcinoma; SCC: Squamous cell carcinoma; BM: Brain metastasis.