Modification in the diet can induce beneficial effects against breast cancer

Table 1 Examples of breast cancer animal models that have demonstrated the beneficial effects of lactic acid bacteria

Model	Results	Mechanisms	LAB	Ref.
4T1 tumour bearing mice	Significant decrease of tumour growth	Modulation of the host’s immune response	L. acidophilus isolated from traditional home-made yogurt and from neonatal stool	[113]
Mice bearing invasive ductal carcinoma	Decrease of tumour growth rate and prolongation of mice survival	Modulation of the host’s immune response	L. casei spp. casei ATCC 39392	[114]
4T1 breast cancer bearing mice	Tumor volumes of mice treated with Se nanoparticle-enriched probiotic were decreased and their survival rate increased compared to mice that received probiotic alone or control mice.	Modulation of the host’s immune response	L. plantarum strain enriched with selenium nanoparticles	[115] [116]
Swiss mice fed a Westernized chow and FVB strain erbB2 (HER2) mutant mice	Inhibition of mammary neoplasia in both models.	LAB triggered CD4+CD25+ lymphocytes that convey transplantable anti-cancer protection.	L. reuteri ATCC-PTA-6475
4T1 breast cancer bearing mice	Decrease of tumour growth in mice fed preventively with LAB and also in mice fed probiotic after tumour detection	Modulation of the host’s immune response and decrease of tumour angiogenesis	L. casei CRL 431	[117]

LAB: Lactic acid bacteria.