Current role of modern radiotherapy techniques in the management of breast cancer

Table 3 Prospective randomized phase III trials of Accelerated Partial Breast Irradiation

Institution/trial	Number of patients	Inclusion criteria	Control arm	Experimental arm
National Institute of Oncology, Budapest, Hungary[80]	258	Wide local excision, > 40 yr, Tm ≤ 20 mm, Invasive ductal carcinoma (non-lobular), Node negative, Margin negative	WBRT (50 Gy in 25 fx)	(1) MIB (36.4 Gy in 7 fx) (2)Electrons (50 Gy in 25 fx)
European Institute of Oncology ELIOT[63,82]	1305	Quadrantectomy, ≥ 48 yr, Tm ≤ 2.5 cm, Invasive carcinoma, Node negative	WBRT (50 Gy in 25 fx) ± 10 Gy boost	IORT (21 Gy in 1 fx, electrons up to 9 MeV)
TARGIT-A[69,81]	3451	Lumpectomy, ≥ 45 yr, Invasive ductal carcinoma (non-lobular), Node negative	WBRT 40–56 Gy ± 10–16 Gy boost	IORT (20 Gy in 1 fx, low-energy X-rays)

Tm: Tumor; WBRT: Whole breast radiotherapy; fx: Fraction; MIB: Multicatheter interstitial brachytherapy; IORT: Intraoperative radiotherapy; DCIS: Ductal carcinoma in situ; 3DCRT: Three dimensional conformal radiotherapy; Gy: Gray.