Biological subtypes of breast cancer: Prognostic and therapeutic implications

Table 1 2013 St. Gallen - intrinsic subtypes of breast cancer

Intrinsic subtype	Clinicopathological surrogate definition
Luminal-A	“Luminal-A-like” all of: ER and PgR positive HER2 negative Ki-67 “low”a Recurrence risk “low” based on multi-gene-expression assay (if available) b	a A level of < 14% best correlated with the gene-expression definition of Luminal A based on the results in a single reference laboratoryb PgR cut-point of ≥ 20% to best correspond to Luminal A subtype
Luminal-B	Luminal-B-like (HER 2 positive) ER positive HER2 negative and at least one of: Ki-67 “high” PgR “negative or low” Recurrence risk “high” based on multi- gene-expression assay (if available)  Luminal-B (HER 2 negative) ER positive HER2 over-expressed or amplified Any Ki-67 Any PgR
Erb-B2 overexpression	HER 2 positive (non-luminal) HER2 over-expressed or amplified ER and PgR absent
Basal-like	Triple negative (ductal) ER and PgR absent HER2 negative	There is an 80% overlap between “triple-negative” and intrinsic “basal-like” subtype