Toremifene in the treatment of breast cancer

Table 3 Incidence of adverse events among 1847 women with invasive breast cancer treated with tamoxifen or toremifene[41]

	Adverse event incidence (%)
Adverse event	Tamoxifen(n = 1451)	Toremifene(n = 396)	P value
Flushing	480 (33.1)	39 (35.1)	0.450
Sweating	295 (20.3)	82 (20.7)	0.869
Nausea or vomiting	213 (14.7)	57 (14.4)	0.881
Fatigue	74 (5.1)	18 (4.5)	0.653
Insomnia	62 (4.3)	14 (3.5)	0.513
Dizziness	14 (1.0)	6 (1.5)	0.408
Dry eyes	60 (4.1)	17 (4.3)	1
Blurred vision	40 (2.8)	9 (2.3)	0.595
Cataracts	7 (0.5)	2 (0.5)	1
Weight gain	68 (4.7)	17 (4.3)	0.740
Vaginal discharge	241 (16.6)	69 (17.4)	0.701
Irregular menses	145 (10)	25 (6.3)	0.025
Endometrial cancer	1 (0.1)	0 (0)	0.601
Ovarian cyst	20 (1.4)	4 (1.0)	0.631
Thromboembolic events	22 (1.5)	5 (1.3)	0.709
Hypertriglyceridemia	76 (5.2)	19 (4.8)	0.725
Hyper-LDL cholesterolemia	65 (4.5)	16 (4.0)	0.783
Fatty liver	64 (4.4)	13 (3.3)	0.320
Elevated ast	59 (4.1)	15 (3.8)	0.802
Elevated alp	33 (2.3)	7 (1.8)	0.571
Hepatic cyst	29 (2.0)	6 (1.5)	0.550
Bilirubin	27 (1.9)	8 (2.0)	1