Paraneoplastic syndromes associated with lung cancer

Table 6 Criteria for the diagnosis of paraneoplastic neurological syndromes[93]

Definite PNS

A classical syndrome and cancer that develops within five years of the diagnosis of the neurological disorder

A non-classical syndrome that resolves or improves significantly after cancer treatment without concomitant immunotherapy, provided that the syndrome is not susceptible to spontaneous remission

A non-classical syndrome with onconeural antibodies (well characterized or not) and cancer that develops within five years of the diagnosis of the neurological disorder

A neurological syndrome (classical or not) with well-characterized onconeural antibodies and no cancer

Possible PNS

A classical syndrome, no onconeural antibodies, and no cancer, but a high risk of an underlying tumor

A neurological syndrome (classical or not) with partially characterized onconeural antibodies and no cancer

A non-classical syndrome, no onconeural antibodies, and cancer present within five years of the diagnosis

PNS: Paraneoplastic neurological syndromes.