MicroRNAs in pathogenesis of breast cancer: Implications in diagnosis and treatment

Table 1 List of major oncogenic microRNAs in breast cancer

MiRNA	Known target mRNA	Function	Ref.
MiR-10b	HOXD10	Promotes cell proliferation, metastasis and angiogenesis	[108]
MiR-126	IGFBP2, MERTK, PITPNC1	Promotes angiogenesis	[18]
MiR-155	SOCS1, TP53INP1, FOXO3, RhoA	Promotes cell proliferation	[12,20,21,62]
MiR-21	PTEN, TPM1, PDCD4, Maspin	Promotes cell proliferation	[22-24,109]
MiR-375	RASD1	Epigenetic modification of tumor suppressor genes	[110,111]
MiR-221/222	TRPS1	Induce metastasis	[28,29,65]
MiR-373	CD-44	Induce metastasis	[14,26]
MiR-520c	CD-44	Induce metastasis	[14,26]
MiR-9	SOCS5, E-cadherin	Induce metastasis	[27,112,113]
MiR-632	DNAJB6	Induce metastasis	[30]
MiR-196b	HOXD10 (indirect)	Promotes angiogenesis	[15]
MiR-7	HOXB3	Epigenetic modification of tumor suppressor genes	[16]
MiR-218	HOXB3	Epigenetic modification of tumor suppressor genes	[16]
MiR-203	SOCS3	Promotes cell proliferation	[25]

HOXD10: Homeobox D10; IGFBP2: Insulin-like growth factor binding protein 2; MERTK: C-mer proto-oncogene tyrosine kinase; PITPNC1: Phosphatidylinositol transfer protein, cytoplasmic 1; SOCS1: Suppressor of cytokine signaling 1; TP53INP1: Tumor protein p53 inducible nuclear protein 1; FOXO3: Forkhead box O3; RhoA: Ras homolog family member A; PTEN: Phosphatase and tensin homolog; TPM1: Tropomyosin 1 (alpha); PDCD4: Programmed cell death 4; RASD1: Rat Sarcoma dexamethasone-induced 1; TRPS1: Trichorhinophalangeal syndrome 1; DNAJB6: DnaJ (Hsp40) homolog, subfamily B, member 6; HOXB3: Homeobox B3; MiRNA: MicroRNA.