Prognostic value of preoperative serum tumor markers in gastric cancer

Table 5 Independent prognostic factors for predicting disease-free survival and overall survival by multivariate analysis using Cox model

Factors	DFS			OS
	HR	95%CI	P	HR	95%CI	P
Age	1.028	0.825-1.770	0.331	0.932	0.667-1.303	0.682
Gender	1.072	0.634-1.814	0.795	0.791	0.543-1.151	0.220
Tumor size	1.718	1.159-2.546	0.007	1.998	1.433-2.785	< 0.001
Differentiation	1.398	0.685-2.853	0.357	0.714	0.398-1.281	0.258
T category	0.796	0.213-2.978	0.734	6.042	2.190-16.668	0.001
N category	1.014	0.836-1.231	0.884	1.734	1.429-2.014	< 0.001
Vascular/nerves invasion	0.930	0.606-1.426	0.739	1.515	1.045-2.195	0.028
Adjuvant chemotherapy	0.931	0.614-1.411	0.736	0.618	0.425-0.898	0.012
CEA	3.045	0.401-23.157	0.282	0.902	0.618-1.316	0.592
CA19-9	0.392	0.045-3.384	0.394	0.836	0.449-1.556	0.571
CA50	1.058	0.546-2.050	0.868	1.470	0.842-2.569	0.176

CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; DFS: Disease-free survival; OS: Overall survival.