Prognostic value of preoperative serum tumor markers in gastric cancer

Table 1 Previous studies reporting the association between preoperative tumor markers and oncologic outcomes

Ref.	CEA	CA199	CA50	Number of	Prognostic impact in overall survival (P value)
	cut-off value	cut-off value	cut-off value	patients	Univariate analysis			Multivariate analysis
	(ng/mL)	(U/mL)	(U/mL)		CEA	CA19-9	CA50	CEA	CA19-9	CA50
Ishigami et al[10]	10	74	NA	549	< 0.0001	< 0.0001		0.040	0.150
Nakane et al[18]	10	NA	NA	865				0.001
Kochi et al[6]	5	37	NA	434	< 0.01	< 0.01		0.044	0.169
Schauer et al[11]	NA	45	NA	120		0.007
Marrelli et al[7]	5	37	NA	153	< 0.0005	< 0.0001		< 0.05	< 0.05
Park et al[8]	7	NA	NA	810	< 0.001			0.005
1Liu et al[12]	10	37	20	273	0.000	0.000	0.000	0.000	0.000	0.006
Liu et al[13]	10	35	25	391	0.000	0.000	0.001	0.006	> 0.05	> 0.05
Gaspar et al[23]	5	35	NA	82				0.770	0.630
Ucar et al[19]	5	35	NA	95				0.500	0.600
Tachibana et al[14]	5	NA	NA	196	< 0.0001			0.000
Duraker et al[15]	5	37	NA	168	0.003	0.014		0.145	0.174
Tocchi et al[16]	3	37	NA	59	< 0.03	< 0.05		0.000	0.014
Lai et al[9]	5	37	NA	196				0.867	0.230
Dilege et al[17]	5	33	NA	75	> 0.05	> 0.05

¹Prognostic significance of tumor markers in T4a gastric cancer. NA: Not available; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen.