Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma

Table 4 Outcomes following Gamma Knife salvage therapy for recurrent glioblastoma multiforme

Ref.	rGBM patients	Med. survival from diagnosis (mo)	Progression-free survival	Median survival after GK salvage (mo)	Time to recurrence, post-GK (mo)	Local tumorcontrol	ARE
Skeie et al[9]	32	18.0 (95%CI: 16.7-30.8)	NR	9 (95%CI: 8.7-14.9)	6	18.8%	9.80%
	19 (salvage GTR)	21.0 (95%CI: 21.2-55.9)		15 (95%CI: 12.8-40.4)
Park et al[10]	11 (salvage BZ)	33.2 (95%CI: 23.7-42.7)	14.9 (95%CI: 6.5-23.3)	17.9 (95%CI: 10.1-25.7)	All 6 tumors > 10 mL: 5.9 (95%CI: 1.8-10.0) 1 of 5 tumors < 10 mL: 9.5	NR	9.00%
	44	26.7 (95%CI: 21.8-31.6)	6.7 (95%CI: 5.6-7.8)	12.2 (95%CI: 8.1-16.3)	19 of 21 tumors > 10 mL: 5.1 (95%CI: 4.0-6.2) 21 of 23 tumors < 10 mL: 8.3 (95%CI: 4.2-12.4)	NR	46%
Koga et al[28]	9	24.0 (range, 14-57)	NR	10.5 (range, 3-29)	NR	47.0%	5.90%
	9 (EF GK)	21.0 (range, 15-51)		9 (range, 6-27)		93.0%	28.6%
Elliott et al[11]	16	26.1	NR	13 (range, 2.5-37.2)	NR	NR	18.8%
Pouratian et al[25]	26	17.4 (95%CI: 14.4-20.4)	7.1 (95%CI: 2.9-11.3)	9.4 (95%CI: 7.9-10.9)	NR	NR	0.0%
Kida et al[21]	54	27.0	NR	14.0	NR	NR	NR
1Kong et al[23]	65	23.0 (95%CI: 16.2-29.3)	4.6 (95%CI: 4.0-5.2)	13 (95%CI: 10.6-16.0)	NR	NR	NR
Kohshi et al[22]	11	21.0 (95%CI: 16-26)	NR	11 (95%CI: 4-12)	NR	NR	18.0%
Hsieh et al[24]	26	16.7	NR	10.0	NR	NR	NR

¹Kong et al[23] (2008) includes data from 0-5 cases treated with LINAC. rGBM: Recurrent glioblastoma multiforme; GK: Gamma knife; ARE: Adverse radiation effects; GTR: Gross total resection; BZ: Bevacizumab; NR: Data not reported or not segregated for rGBM patients.