Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma

Table 2 Upfront treatment modalities for newly diagnosed glioblastoma multiforme

Ref.	rGBM patients	Initial surgery	Adjuvant rad	Adjuvant chemotherapy	Time to 1st recurrence (mo)
Skeie et al[9]	32	All GTR	93.5% of patients had EBRT	37% Temo, 19.9% PCV	11.0 (mean)
	19		(39-60 Gy)		10.4 (mean)
Park et al[10]	11	4 Bx, 7 GTR	All EBRT (54-60 Gy)	All Temo	NR
	44	NR	NR	NR
Koga et al[28]	9	All resection	8 EBRT (48-80 Gy)	6 ACNU, 2 Temo, 1 CE	14.5 (median) (range, 1-51)
	9	2 Bx, 7 resection	All EBRT (60-80 Gy)	All Temo	12 (median) (range, 6-39)
Elliott et al[11]	16	NR	All EBRT (60 Gy)	All Temo	7.9 (median) (range, 2-84)
Pouratian et al[25]	26	2 Bx, 18 STR, 6 GTR	25 EBRT (dose NR)	16 had chemotherapy (type NR)	NR
Kida et al[21]	54	NR	NR	NR	NR
1Kong et al[23]	65	NR	All EBRT (54-70 Gy)	NR	4.3 (range, 1.5-27.0)
Kohshi et al[22]	11	All debulking	All EBRT (50-72 Gy)	All had chemotherapy (type NR)	NR
Hsieh et al[24]	26	NR	All EBRT (60 Gy)	NR	NR

¹Kong et al[23] (2008) includes data from 0-5 cases treated with LINAC. rGBM: Recurrent glioblastoma multiforme; GTR: Gross total resection; STR: Subtotal resection; Bx: Biopsy; EBRT: External beam radiation therapy; Temo: Temozolomide; PCV: Procarbazine, lomustine, and vincristine; NR: Data not reported or not segregated for rGBM patients.