Temozolomide for treatment of brain metastases: A review of 21 clinical trials

Table 2 Study characteristics of the studies that combined temozolomide with radiotherapy and/or other agents

Trial	Publication information(author/yr/country)	Patient characteristic			Cancer	Prior treatment
		Total number	Median age	Gender (male/female)
8	Addeo et al[22]/2008/Italy	27	55	13/14	NSCLC (n = 15) Breast (n = 12)	Chemotherapy (n = 20) Surgery (n = 20) Radiotherapy (n = 12)
9	Mikkelsen et al[23]/2010/United States	17	65.4	10/7	Lung (n = 13) Colon (n=1) Melanoma (n = 1) Mixed (prostate, bladder, lung) (n = 1) Unknown (probably lung) (n = 1)	Chemotherapy (n = 7) Surgery (n = 1) Stereotactic radiosurgery (n = 2)
10	Kouvaris et al[24]/2007/Greece	33	66	22/11	SCLC (n = 4) NSCLC (n = 10) Breast (n = 7) Rectal (n =5) Melanoma (n = 5) Oral cavity (n = 1) Unknown (n = 1)	NA
11	Hofmann et al[25]/2006/Germany	35 (341)	53	19/16	Melanoma	Chemotherapy (n = 7) Immunotherapy (n = 4) Chemoimmunotherapy (n = 3) Surgery/radiosurgery (n = 4)
12	Antonadou et al[26]/2002/Greece	25 (241)	49	25/14	Melanoma	NA
13	Atkins et al[29]/2008/United States	39	61	29/10	Melanoma	Immunotherapy (n = 12) Radiotherapy (n = 7)
14	Cortot et al[28]/2006/France	50 (472/333/474)	57	40/10	NSCLC	Surgery (n = 40) Radiotherapy (n = 3)
15	Iwamoto et al[31]/2007/United States	38 (361)	57	15/23	NSCLC (n = 17) SCLC (n = 3) Breast (n = 11) Colon (n = 2) Renal (n = 2) Endometrial (n = 1) Bladder (n = 1) Head and neck (n = 1)	Chemotherapy (n = 37) WBRT (n = 30) Surgery (n = 20) Stereotactic radiosurgery (n = 18)
16	Larkin et al[32]/2006/United Kingdom	26 (141)	50	14/12	Melanoma	Immunotherapy (n = 7) Radiosurgery (n = 1) Surgery (n = 1)
17	Caraglia et al[33]/2005/Italy	19	63	7/12	Breast (n = 8) NSCLC (n = 6) Colo-rectal (n = 3) Melanoma (n = 1) Ovarian (n = 1)	Systemic treatment (n = 12 ) Radiotherapy(out of brain) (n = 3) WBRT (n = 13)
18	Bael et al[34]/2007/United States	11 (51)	50	8/3	Melanoma	Immunotherapy (n = 3)
19	Christodoulou et al[35]/2005/Greece	32 (211)	53	11/21	Breast (n = 15) NSCLC (n = 11) SCLC (n = 1) Gastric (n = 1) Melanoma (n = 3) Unknown (n = 1)	Chemotherapy (n = 27) Radiotherapy (n = 17) Surgery (n = 1)
20	Hwu et al[30]/2005/United States	26 (142/153)	60	14/12	Melanoma	WBRT (n = 8) Stereotactic radiosurgery (n = 4) Surgery (n = 4)
21	Bafaloukos et al[27]/2004/Greece	25 (241)	48	15/10	Melanoma	NA

¹The number of patients eligible for the assessment of clinical outcomes;

²The number of patients eligible for the assessment of brain lesion response;

³The number of patients eligible for the assessment of extracerebral response;

⁴The number of patients eligible for the assessment of global response. TMZ: Temozolomide; NA: Not available; NSCLC: Non–small cell lung cancer; WBRT: Whole-brain radiotherapy.