Current aspects of therapeutic reduction mammaplasty for immediate early breast cancer management: An update

Table 2 Oncological and outcome evidence for delivery of adjuvant chemotherapy after immediate breast-conservation surgery reconstruction

Ref.	Year	n	Tumor size (cm)	Adjuvant chemotherapy n (%)	Delay in chemotherapy	Delayed adjuvant chemotherapy n (%)
Nos et al[71]	1998	50	Tis-T4	5 (10)	+	3 (6)
Losken et al[23]	2002	20	Tis-N/D	N/D	-	0
Clough et al[41]	2003	101	T1-T4	0	+	4 (4)
Spear et al[18]	2003	22	N/D	22 (100)	-	0
McCulley et al[53]	2005	50	Tis-N/D	23 (46)	-	0
Munhoz et al[15]	2006	74	T1-T2	22 (29.7)	-	0
Thornton et al[54]	2006	6	T1-T2	0	-	0
Kronowitz et al[50]	2007	41	Tis-T2	18 (44)	-	0
Losken et al[25]	2007	63	Tis-N/D	N/D	-	0
Rietjens et al[42]	2007	148	T1-T3	89 (60)	-	0
Meretoja et al[72]	2010	90	Tis-T3	60 (67)	+	2 (2)
Fitoussi et al[47]	2010	540	T1-T3	N/D	+	10 (1.9)
Song et al[55]	2010	28	Tis	N/A	-	0
Romics et al[56]	2012	31	T1-T3	31 (100)	-	0
Kahn et al[28]	2013	169	T1-T3	N/D	-	0

N/D: Not disclosed; N/A: Not applicable; (+): Positive; (-): Negative.