Review
Copyright ©2012 Baishideng Publishing Group Co.
World J Clin Oncol. May 10, 2012; 3(5): 67-79
Published online May 10, 2012. doi: 10.5306/wjco.v3.i5.67
Table 1 The human matrix metalloproteinase family
MMPAlternative namesGroupSubstrates
MMP-1Collagenase-1, interstitial collagenase, fibroblast collagenase, tissue collagenaseCollagenasesAggrecan, collagen I,II, III, VII, VIII, X, XI, entactin/nidogen, fibronectin, gelatin I, IGFBPs, laminin, link protein, myelin basic, tenascin, vitronectin, α 1-AC, α 2-M, α1-PI, casein, C1q, fibrin, fibrinogen, IL1β, proTNFα, serpins
MMP-2Gelatinase A, 72-kDa gelatinase, 72-kDa type IV collagenase, neutrophil gelatinaseGelatinasesAggrecan, collagen I, III, IV, V, VII, X, XI, decorin, elastin, entactin/nidogen, fibrillin, fibronectin, fibulins, gelatin I, IGFBPs, laminin, link protein, myelin basic, osteonectin, tenascin, vitronectin, α1-AC, α 1-PI, C1q, fibrin, fibrinogen, IL1β, monocyte chemoattractant protein 3, proTGF β, proTNF α, plasminogen, substance P, T kininogen
MMP-3Stromelysin-1, transin-1, proteoglycanase, procollagenase activating proteinStromelysinsAggrecan, collagen III, IV, V, VII, IX, X, XI, decorin, elastin, entactin/nidogen, fibrillin, fibronectin, gelatin I, IGFBPs, laminin, link protein, myelin basic, osteonectin, tenascin, vitronectin, α1-AC, α 2-M, α 1-PI, casein, C1q, E-cadherin, fibrin, fibrinogen, IL1β, osteopontin, proTNF α, plasminogen, substance P
MMP-7Matrilysin, matrin, PUMP1, small uterine metalloproteinaseMatrilysinsAggrecan, collagen I, IV, decorin, elastin, entactin/nidogen, fibronectin, fibulins, gelatin I, laminin, link protein, myelin basic, osteonectin, tenascin, vitronectin, α 1-PI, casein, E-cadherin, fibrinogen, proTNF α, plasminogen, versican
MMP-8Collagenase-2, neutrophil collagenase, PMN collagenase, granulocyte collagenaseCollagenasesAggrecan, collagen I,II, III, IX, X, α 2-M, α 1-PI, C1q, E-cadherin, fibrinogen, laminin, serpins, substance P
MMP-9Gelatinase B, 92-kDa gelatinase, 92-kDa type IV collagenaseGelatinasesAggrecan, collagen IV, V, VII, X, XI, XIV, decorin, elastin, fibrillin, gelatin I, laminin, link protein, myelin basic, osteonectin, vitronectin, α 2-M, α 1-PI, casein, C1q, fibrin, fibrinogen, IL1β, proTGF β, proTNF α, plasminogen, substance P
MMP-10Stromelysin-2, transin-2StromelysinsAggrecan, collagen III, IV, V, elastin, fibronectin, gelatin I, link protein, casein, fibrinogen, osteopontin
MMP-11Stromelysin-3Other MMPsIGFBPs, α 2-M, α 1-PI, serpins
MMP-12Metalloelastase, macrophage elastase, macrophage metalloelastaseStromelysinsAggrecan, collagen I, IV, elastin, entactin/nidogen, fibrillin, fibronectin, gelatin I, laminin, myelin basic, vitronectin, apolipoprotein A, α 2-M, α 1-PI, factor XII, fibrinogen, proTNF α, plasminogen
MMP-13Collagenase-3CollagenasesAggrecan, collagen I,II, III, VI, IX, X, XIV, fibrillin, fibrin, fibronectin, gelatin I, laminin, osteonectin, α 2-M, casein, C1q, factor XII, fibrinogen, perlecan, pro-MMP2, serpins
MMP-14MT1-MMP, MT-MMP1Membrane-type MMPsAggrecan, collagen I,II, III, entactin/nidogen, fibrillin, fibronectin, gelatin I, laminin, vitronectin, α 2-M, α 1-PI, factor XII, fibrin, fibrinogen, proMMP2, proTNF α
MMP-15MT2-MMP, MT-MMP2Membrane-type MMPsAggrecan, fibronectin, laminin, nidogen, perlecan, tenascin
MMP-16MT3-MMP, MT-MMP3Membrane-type MMPsCartilage proteoglycans, casein, collagen III, fibronectin, gelatin, laminin, α 2-M
MMP-17MT4-MMP, MT-MMP4Membrane-type MMPsFibrin, fibrinogen, TNF precursor
MMP-19RASI-1, MMP-18Other MMPsAggrecan, collagen I, IV, fibronectin, gelatin I, laminin, nidogen, cartilage oligometric matrix protein, casein, tenascin
MMP-20EnamelysinOther MMPsAmelogenin, aggrecan, cartilage oligometric matrix protein
MMP-21Homologue of Xenopus XMMPOther MMPsND
MMP-23Cysteine array MMP (CA-MMP), femalysin, MIFR, MMP-21/MMP-22, MMP-23A/MMP-23B1Other MMPsMcaPLGLDpaARNH 2 (synthetic MMP substrate)
MMP-24MT5-MMP, MT-MMP5Membrane-type MMPsProteoglycans
MMP-25MT6-MMP, MT-MMP6, leukolysinMembrane-type MMPsCollagen IV, gelatin, fibrin, fibronectin
MMP-26Endometase, matrilysin-2MatrilysinsCollagen IV, fibronectin, gelatin I, α 1-PI, fibrinogen, TACE substrates
MMP-27Other MMPsND
MMP-28EpilysinOther MMPsCasein